The textbook for the discipline «Evidence-Based Medicine» meets the requirements of the federal state educational standard for higher education in the specialty 31.05.01 General Medicine and the requirements of the Federal State Educational Standard for Higher Education (2020). Intended for students studying in the specialty of higher education «General Medicine». This textbook covers the concept of evidence-based medicine, asking clinical questions, searching for evidence-based information, organizing and conducting statistical research in the field of medicine and presenting their results. There are questions, test tasks and situational tasks for self-testing of knowledge. The textbook is illustrated with drawings, diagrams and tables.