Covers new topics like DADA2 and VEXAS. Six sections devoted to different aspects of systemic vasculitides. In-depth introduction to epidemiology, classification, and genetics of systemic vasculitides. Role of neutrophils, antineutrophil cytoplasmic antibodies, and details of skin, nerves and brain, lungs, and kidney pathology. Imaging modalities as they have assumed a significant role in diagnosing and assessing disease activity. Detailed clinical manifestations based upon organ system or individual vasculitis syndromes. Approach to children and adults with vasculitis and assessing disease activity and damage. Newer and future treatment modalities.