Содержание
7 INTRODUCTION
8 CHAPTER 1: IMMUNE SYSTEM, STRUCTURAL AND FUNCTIONAL FEATURE. THE CONCEPT OF INNATE AND ADAPTIVE IMMUNITY
12 1.1 Structural and functional organization of the immune system
13 1.1.1 The central organs of the immune system
16 1.1.2 Peripheral organs and tissues of the immune system
22 CHAPTER 2: STRUCTURES RECOGNIZED BY THE IMMUNE SYSTEM
22 2.1 Antigens and haptens
22 2.1.1 Defnition of antigen, the main properties of antigens
25 2.1.2 Types of antigens
27 2.2 Structures recognized by the innate immune system
29 CHAPTER 3: INNATE IMMUNITY
30 3.1 Recognition of «foreign» by the innate immune system. Innate immune receptors
37 3.2 Cells of the innate immune system
37 3.2.1 Innate cells of the myeloid lineage
48 3.2.2 Lymphoid cells with innate immunity functions
51 3.3. Humoral factors of the innate immune system
57 CHAPTER 4: MAJOR HISTOCOMPATIBILITY COMPLEX
58 4.1 MHC structure and functions
58 4.1.1 Discovery
59 4.1.2 Genetic map of the human major histocompatibility complex
59 4.1.3 Features of the major histocompatibility complex
60 4.2 MHC class I molecules
61 4.3 MHC class II molecules
62 4.4 Endogenous antigen-processing pathway
63 4.5 Exogenous antigen-processing pathway
64 4.6 HLA disease association
65 CHAPTER 5: CYTOKINES
66 5.1 Classification of cytokines
68 5.2 Characteristics of cytokineproducing cells. Concept of Th1, Th2 and Th17 subpopulations
70 5.3 Characteristics of some cytokines
71 5.4 Cytokine receptors
72 5.5 Cytokines and infammation. Local and systemic effects of cytokines
75 CHAPTER 6: ADAPTIVE IMMUNITY
75 6.1 T-lymphocytes. The main markers and receptors. Features of antigen recognition. The main subpopulations, the functions of lymphocytes
76 6.1.1 Main characteristics of T-lymphocytes
77 6.1.2 The structure of the T-cell receptor
78 6.1.3 T-lymphocyte development
85 6.2 B-lymphocytes. The main markers and receptors. Specifics of antigen recognition. The main subpopulations and functions
86 6.2.1 Main characteristics of B-lymphocytes
87 6.2.2 Subpopulations of B-lymphocytes
88 6.2.3 BCR structure
88 6.2.4 B-lymphocyte markers
89 6.2.5 Antigen-independent differentiation of B-lymphocytes
92 6.3 Antibodies
93 6.3.1 General characteristics and structure of the antibody molecule
94 6.3.2 Mechanisms of antigen-antibody interactions
95 6.3.3 Properties and effector functions of immunoglobulins
97 6.3.4 Characteristics of the main classes of immunoglobulins
99 CHAPTER 7: IMMUNE RESPONSE
101 7.1 Phases of the immune response
101 7.2 Types of immune response and factors determining the development of an immune response
103 7.3 Cell-mediated cytotoxicity
108 7.4 Humoral immune response
111 7.5 Mucosal immunity
114 CHAPTER 8: HYPERSENSITIVITY REACTIONS
116 8.1 Type I Hypersensitivity Reaction
125 8.2 Type II Hypersensitivity Reaction
131 8.3 Type III Hypersensitivity Reaction
141 8.3 Type IV Hypersensitivity Reaction
149 REFERENCES
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Fundamentals of immunology

Авторы: Barycheva L. Y., Ukhanova O. P., Minasyan M. M., ... Khachirova L. S.
Medvedenko Y. N.
Dushina L. V.
Kuzmina E. S.
Kozmova N. A.
Kubanova L. T.
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