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1 UUnit – I. Experimental Animal Studies
2 1. Laboratory Animals
9 2. CPCSEA Guidelines
14 3. OECD Guidelines
18 4. OCED for Good Laboratory Practice (GLP)
22 5. Transgenic and Mutant Animals
27 6. Blood Collection Techniques
32 7. Euthanasia
39 Unit – II. Preclinical Screening Models
40 1. Dose Selection
44 2. Preparation of Solutions of Some Unstable and/or Insoluble Compounds
48 3. Importance of Sham Negative and Positive Control Group
50 4. Screening Models
85 Unit – III. Preclinical Screening Models of A.N.S. Activities
86 1. Drugs Acting on Sympathetic Nervous System
95 2. Drugs Acting on Parasympathetic Nervous System
101 3. Skeletal Muscles Relaxants
104 4. Screening Models for Peripherally Acting Muscle Relaxants
106 5. Drugs of Eyes
112 6. Local Anaesthetics
121 Unit – IV. Presymptomatic Trial Model
122 Part 1: Preclinical Screening Models
122 1. Antihypertensives
128 2. Diuretic Models
134 3. Antiarrhythmic Activities
138 4. Coagulants
141 5. Antiaggregatory Method
146 6. Antiulcer
152 7. Antidiabetics
155 8. Anticancer Agents
159 9. Antiasthmatic Model
166 Part 2: Research Methodology and Bio-Statistics
166 1. Research Methodology
172 2. Literature Review
176 3. Research Hypothesis and Study Design
179 4. Student’s ‘t’ Test
182 5. Analysis of Variance
184 6. One Way ANOVA
186 7. Graphical Representation of Data
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Experimental Pharmacology

Авторы: Anupam Kr. Sachan ., Gupta D., Singh S., ... Singh A.
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